mechanisms and pathways of heterotrimeric g protein

Mechanisms and Pathways of Heterotrimeric G Protein

ISBN: , SKU: , AUTHOR: Sprang, Stephen R., PUBLISHER: Academic Press, This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GƒNƒnƒnproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins.

Ingenious Mechanisms Vol I

ISBN: , SKU: , AUTHOR: Jones, Franklin Day, PUBLISHER: Industrial Press, The descriptions and illustratios are confined to the important and fundamental elements, so that time is not wasted reading a lot of useless or irrelevant detail. Readers are told plainly and briefly what each mechanism consists of, how it operates, and the features which make it of special interest. The particular mechanisms have been selected because they have stood the test of actual practice. Among the mechanisms described and illustrated by working diagrams are: cam applications and special cam designs; intermittent motions from gears and cams; interlocking devices; valve diagrams; reversing mechanisms of special design; tripping or stop mechanisms; drives of crank type for reciprocating driven members; feeding mechanisms and auxiliary devices; feeding and ejecting mechanisms; and many, many more.

Mechanisms of Surface and Microstructure Evolution in

ISBN: , SKU: , AUTHOR: Sanchez Jr, John / Amar, J. G. / Gilmer, G. H., PUBLISHER: Materials Research Society, A wide variety of materials systems and deposition strategies have been developed to produce epitaxial and polycrystalline thin films. In particular, controlling the morphology and microstructure of metal films at the nanometer and/or micron scale has become crucial for applications such as giant magneto-resistive devices, contacts and diffusion barriers in integrated circuits and photovoltaics, and multilayer X-ray mirrors. This volume focuses on the interactions between different mechanisms of microstructure evolution and film-growth conditions. Two sections of the volume, including a joint effort with Symposium R, "Morphology and Dynamics of Crystal Surfaces in Molecular and Colloid Systems, highlight the fundamental mechanisms of epitaxial growth.

Pathways of Care

ISBN: , SKU: , AUTHOR: Johnson, Sue / Johnson, S., PUBLISHER: Wiley-Blackwell, Pathways of Care programmes are used in all areas of healthcare to improve clinical effectiveness and the quality of patient care. This book is an essential reference source for all those involved in coordinating healthcare delivery. It is also a valuable tool for those piloting the use of Pathways, for those who have already implemented Pathway programmes, and for anyone interested in investigating or using Pathways. The book provides detailed information on the concepts of Pathways and many examples of how Pathways of care have been implemented and used in different clinical settings. The text considers key topics including clinical guidelines, legal issues, risk management and analysis of variation. With contributions from experts in a wide range of settings--including community and mental health, cardiology, urology, orthopaedics and paediatrics--this well-referenced text draws on practical experiences in identifying, evaluating and modifying the process of healthcare delivery.

Concerted Organic and Bio-Organic Mechanisms

ISBN: , SKU: , AUTHOR: Williams, Andrew, PUBLISHER: CRC Press, The concept of concerted mechanisms was formulated nearly 90 years ago and virtually all general organic chemistry texts mention it. Until now, however, no monograph has addressed the concept explicitly. Over the last two decades, substantial advancements made in the development of precise methods for elucidating concerted mechanisms have heightened the need for a comprehensive text on the subject. Concerted Organic and Bio-organic Mechanisms gathers the salient materials related to this emerging field into a single text. It sets forth the precise definition of concertedness-along with working sub-definitions-and describes rigorous experimental tools chemists can use to diagnose the existence or absence of concerted mechanisms. Advances in our understanding of concerted mechanisms lead to further questions. Concerted Organic and Bio-organic Mechanisms provides the background and the tools researchers need to consider these important questions and further advance the frontiers of reactions, synthesis, and catalysis.

The Design of Animal Communication

ISBN: , SKU: , AUTHOR: Hauser, Marc D. / Konishi, Mark, PUBLISHER: MIT Press (MA), When animals, including humans, communicate, they convey information and express their perceptions of the world. Because different organisms are able to produce and perceive different signals, the animal world contains a diversity of communication systems. Based on the approach laid out in the s by Nobel laureate Nikolaas Tinbergen, this book looks at animal communication from the four perspectives of mechanisms, ontogeny, function, and phylogeny. The book's great strength is its broad comparative perspective, which enables the reader to appreciate the diversity of solutions to particular problems of signal design and perception. For example, although the neural circuitry underlying the production of acoustic signals is different in frogs, songbirds, bats, and humans, each involves a set of dedicated pathways designed to solve particular problems of communicative efficiency. Such comparative findings form the basis of a conceptual framework for understanding the mechanisms underlying communication systems and their evolution.

Atomistic Mechanisms in Beam Synthesis and Irradiation:

ISBN: , SKU: , AUTHOR: Barbour, John Charles / Roorda, S. / Ila, D., PUBLISHER: Materials Research Society, This volume focuses on understanding the atomistic processes that occur in metals, ceramics (including glasses) and polymers that are exposed to energetic beams for the purpose of synthesizing or modifying a material. In particular, emphasis is given to atomistic approaches for modeling and understanding experimental results. The science presented falls into four categories: (1) surface and thin-film microstructures driven by ion-beam processing, including mechanisms for driving preferential orientation in single-crystal and polycrystalline formations; (2) comparisons and contrasts in the mechanisms involved with high energy, ion-beam radiation and high-fluence-rate effects; (3) identification of mechanisms in beam-assisted synthesis of materials; and (4) atomistic modeling to describe improved mechanical and optical properties of coatings and layers treated with ion beams.

Protein Conformation - No. 161

ISBN: , SKU: , AUTHOR: Ciba Foundation / Caba Foundation, PUBLISHER: John Wiley & Sons, Protein Conformation Chairman: F.M. Richards One of the major unsolved problems in biology and chemistry is how the amino acid sequence of a protein determines its three-dimensional structure, yet this structure is fundamental to the functioning and mechanism of action of enzymes, channels and receptors. Since the pioneering modelling work of Pauling in the s and the X-ray structure determinations by Kendrew and Perutz in the s, much structural information on proteins has been amassed. Several hundred protein structures have now been solved by X-ray crystallography and, more recently, NMR spectroscopy has had a significant impact on the study of structures of small proteins in solution. In this book, contributions from experts in the fields of X-ray crystallography, NMR spectroscopy, molecular modelling and protein engineering provide insight into current views on the protein folding problem and point to avenues for future progress. The use of molecular dynamics simulations to provide information about protein structure, dynamics and stability, and about protein-- protein interactions, is discussed. Other topics focused on include enzyme catalysis, site-directed mutagenesis as a tool in studies of protein conformation and stability, and recent developments in multidimensional NMR methodology. Related Ciba Foundation Symposia No 159 Catalytic antibodies Chairman: W.P. Jencks ISBN X No 158 Host-guest molecular interactions: from chemistry to biology Chairman: I.O. Sutherland ISBN No 145 Carbohydrate recognition in cellular function Chairman: E. Ruoslahti ISBN No 119 Synthetic peptides as antigens Chairman: G.L. Ada ISBN

Black and Mormon

ISBN: , SKU: , AUTHOR: Bringhurst, Newell G. / Smith, Darron T., PUBLISHER: University of Illinois Press, The year marked the twenty-fifth anniversary of the lifting of the ban excluding black members from the priesthood of the Mormon church. The articles collected in Newell G. Bringhurst and Darron T. Smith's Black and Mormon look at the mechanisms used to keep blacks from full participation, the motives behind the ban, and the kind of changes that have--and have not--taken place within the church since the revelation responsible for its end. This challenging collection is required reading for anyone concerned with the history of racism, discrimination, and the Latter-day Saints.

Memory and Context for Language Interpretation

ISBN: , SKU: , AUTHOR: Alshawi, Hiyan / Boguraev, Branimir / Bird, Steven, PUBLISHER: Cambridge University Press, This book presents computational mechanisms for solving common language interpretation problems including many cases of reference resolution, word sense disambiguation, and the interpretation of relationships implicit in modifiers. The proposed memory and context mechanisms provide the means for representing and applying information about the semantic relationships between entities imposed by the cultural context. The effects of different 'context factors', derived from multiple sources, are combined for disambiguation and for limiting memory search; the factors having been created and manipulated gradually during discourse processing.

Bacterial Responses to PH - No. 221

ISBN: , SKU: , AUTHOR: Chadwick, Derek / Cardew, Gail / Gardew, Gail, PUBLISHER: John Wiley & Sons, Microbial responses to acidic and alkaline pH are important in many areas of bacteriology. For example, the mechanisms of resistance to acidic pH are important in the understanding of the passage of human pathogens through the acid of the stomach; and an understanding of microbial degradation of alkaline industrial waste is important for the environment. Bringing together contributions from an international and interdisciplinary group of experts working on the many aspects of bacterial cellular responses to pH, this stimulating volume draws together new and innovative work in this area. It delineates both similarities and differences between mechanisms of tolerance and response, providing readers with an invaluable resource on the subject.

Enzyme Kinetics: In Focus

ISBN: , SKU: , AUTHOR: Cornish-Bowden, A. / Wharton, C. W. / Cornish-Bowden, Athel, PUBLISHER: Oxford University Press, USA, There is a core of enzyme kinetics that every biochemist needs to be familiar with, and every biochemistry student needs to be taught. This textbook presents that core in a logical and helpful manner and links traditional ideas on enzyme kinetics with the latest theories about enzyme mechanisms. It also discusses the possible implications of protein engineering. Students will find this book an invaluable aid in a notoriously difficult subject.

Molecular Biology of Parasitic Protozoa

ISBN: , SKU: , AUTHOR: Smith, Parsons / Smith, Deborah Ed. / Smith, Deborah F., PUBLISHER: Oxford University Press, USA, Protozoans are interesting creatures for several reasons, not least of which is their ability to live inside or among the cells of their host while resisting the host's cellular defences. The rigours of their lifestyle have resulted in the evolution of some remarkable adaptation at the biochemical level; many parasites have dispensed with entire metabolic pathways, and have evolved complex mechanisms for transmission to new hosts. Parasitic protozoa cause some of the major infectious diseases of humans and domestic animals. In recent years, new molecular biological techniques have opened up the study of the biology of these parasites, and tremendous advances have been made. This book covers this interesting and fast-moving field at an advanced level for which there is no other up-to-date book.

Molecular and Genetic Aspects of Nitrate Assimilation

ISBN: , SKU: , AUTHOR: Wray, John L. / Kinghorn, James R., PUBLISHER: Oxford University Press, USA, There is considerable interest in the mechanisms of nitrate regulation from both agriculture and industry because effective nitrate metabolism is vital for healthy plant growth. This book addresses aspects of both fungal and higher plant metabolism. It examines the genetics and molecular biology of nitrate uptake, reduction, and regulation, and identifies future research priorities.

Possible Mechanisms of the Neostriatum in Regulation of

ISBN: , SKU: , AUTHOR: N G Khrushchov T M Turpaev, PUBLISHER: Routledge, NA Acquista Ora

Negative Co-Receptors and Ligands

ISBN: , SKU: , AUTHOR: Ahmed, Rafi / Honjo, Tasuku, PUBLISHER: Springer, Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or downmodulation to avoid excessive damage to the host tissue. For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands have been identified that control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes biological functions as well as molecular mechanisms of these molecules.

Interactive Biochemistry CD-ROM and Workbook

ISBN: , SKU: , AUTHOR: Grisham, Charles M. / Holt Rinehart & Winston, PUBLISHER: Thomson Brooks/Cole, This multimedia tool contains 16 modules, including Bioenergetic Calculations, Biomolecules, Amino Acids, Peptide Bonds, and Protein Structures, Sweet Isomers, Structures of Phospholipids, Nitrogenous Bases, and Nucleosides, Restriction Sites, Enzyme Kinetics and Mechanisms, metabolism and metabolic map Database, and Virtual Biochemical World. Icons integrated throughout Garrett and Grisham's, BIOCHEMISTRY, Second Edition and PRINCIPLES OF BIOCHEMISTRY: A HUMAN FOCUS, First Edition and Campbell's BIOCHEMISTRY, Third Edition prompt students to explore and engage in the activities and exercises provided on the INTERACTIVE BIOCHEMISTRY CD-ROM. Covering every major area of biochemistry, INTERACTIVE BIOCHEMISTRY CD-ROM features 120 Java Applets, 82 Chimea Tutorials, 8 Virtual Reality scenes, 600 Chimea structures of Intermediary Metabolites, and interactive problem-solving simulations. The CD-ROM and Workbook are designed to enhance classroom lectures as well as to assist students outside of the classroom. The workbook, which is packaged with the CD-ROM, guides students through the CD modules. Students are asked biochemical questions and they answer the questions in the workbook. The CD-ROM and workbook are value priced when packaged with the text.

Molecular Variability of Fungal Pathogens

ISBN: , SKU: , AUTHOR: Bridge, Paul Dennis / Clarkson, John / Couteaudier, Yvonne, PUBLISHER: CABI Publishing, This volume collects important current research on molecular variability in fungal pathogens. The first section reviews the major mechanisms involved. This is followed by a series of specific studies on variability in populations of different fungal pathogens. The book concludes with chapters on methods for interpreting such variability. The volume brings together research on a wide range of fungal pathogens, and case studies include pathogens of insects, nematodes, plants, and humans. Combining mechanisms, characterization, and interpretation across a wide range of applied mycology, this volume is a significant general text for those working on molecular characterization. Its broad spectrum of topics provides a multidisciplinary reference source within mycology, and the book will be suitable for postgraduate students and research scientists in applied mycology, including plant pathology, medical mycology and biological control.

Yugoslavia Unraveled: Sovereignty, Self-Determination,

ISBN: , SKU: , AUTHOR: Thomas, Raju G. C. / Thomas, Raju G. / Bardos, Gordon H., PUBLISHER: Lexington Books, Editor Raju G. C. Thomas and contributors examine underlying issues regarding the sources of religious nationalism and ethnic conflict, the territorial integrity and sovereignty of states, and the principle of self-determination and the right of secession from an existing state. Acquista Ora

Clinical Thrombosis

ISBN: , SKU: , AUTHOR: Kwaan, Hau C. / Samama, Meyer / O'Kelly, Charles J., PUBLISHER: CRC Press, State-of-the-art information on the topic of clinical thrombosis, including an introductory portion dealing with the principles of hemostasis and the pathogenesis of thrombosis, is presented in this text. The use of thrombolytic therapy in acute myocardial infarction is discussed. Other significant advances, such as the identification and understanding of the risk factors contributing to thrombosis such as Protein C and S deficiency, lupus anticoagulants, immune heparin-induced thrombocytopenia, new diagnostic techniques and newer modalities of therapy, are described. Clinical and pathophysiologic features of thrombosis disorders and special situations involving multiple organs are covered. This book also clarifies and updates the usefulness of the various diagnostic techniques.

Antibody Production

ISBN: , SKU: , AUTHOR: Glyn, Leonard Eleazar / Glynn, L. E. / Glynn, Leonard E., PUBLISHER: John Wiley & Sons, A practical guide to the production of antibodies. Describes the biosynthesis of antibody molecules by B lymphocytes and their progeny, the use of genetic markers in the elucidation of mechanisms of antibody synthesis, and of the generation of antibody diversity. Also deals with anomalies in antibody production which result in immunoglobulinopathies, involving qualitative or quantitative abnormalities, or both, in the immunoglobulins.

Immunology: A Short Course

ISBN: , SKU: , AUTHOR: Coico, Richard / Sunshine, Geoffrey, PUBLISHER: Wiley-Blackwell, "Immunology: A Short Course, Sixth Edition" introduces all the critical topics of modern immunology in clear and succinct yet comprehensive fashion. The authors offer a uniquely balanced coverage of classical and contemporary approaches, basic and clinical aspects. As with the previous editions, the strength of the text is in a complete review of modern immunology without burdening the reader with excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics illustrated by uniformly drawn, full-color illustrations, many brand new to this edition. The sixth edition of this successful textbook newly covers: Toll-like receptors, their ligands and intracellular activation pathways The key role of activation induced cytidine deaminase (AID) in somatic hypermutation and class switch recombination. The autoimmune regulator ("AIRE)" gene in self-tolerance and autoimmunity T and B cell activation and the immunological synapse, as well as characterization and mechanisms of action of T regulatory cells Praise for the previous edition: "This book is clearly a precious resource for undergraduate, graduate and medical students alike... For those who need an introduction to the fascinating world of immunology, this book should most certainly spark the interest." "ANNALS OF BIOMEDICAL ENGINEERING"..". an excellent beginner's guide... the authors have done a terrific job of providing an overview of the field." "YALE JOURNAL OF BIOLOGY AND MEDICINE"

Computational Approaches to Morphology and Syntax

ISBN: , SKU: , AUTHOR: Roark, Brian / Sproat, Richard, PUBLISHER: Oxford University Press, USA, The book will appeal to scholars and advanced students of morphology, syntax, computational linguistics and natural language processing (NLP). It provides a critical and practical guide to computational techniques for handling morphological and syntactic phenomena, showing how these techniques have been used and modified in practice. The authors discuss the nature and uses of syntactic parsers and examine the problems and opportunities of parsing algorithms for finite-state, context-free and various context-sensitive grammars. They relate approaches for describing syntax and morphology to formal mechanisms and algorithms, and present well-motivated approaches for augmenting grammars with weights or probabilities.

Pathways to Cultural Awareness: Cultural Therapy with

ISBN: , SKU: , AUTHOR: Spindler, George D. / Spindler, George / Spindler, Louise, PUBLISHER: Corwin Press, Cultural therapy is a way of helping people cope with cultural diversity and societal inequity through the mediation of the school as a central institution for cultural transmission and maintenance. This book illustrates how cultural therapy can be applied in educational settings to promote better understanding among teachers and students. Each chapter presents a situation in which the author has been intimately involved, offering a variety of approaches to, and interpretations of, cultural therapy.

Oatley: Cities, Economic (P) Competition and Urban Policy

ISBN: , SKU: , AUTHOR: Oatley, Nick, PUBLISHER: Sage Publications (CA), This book is a comprehensive and authoritative account of the major realignment that has taken place in English regeneration policy and practice since . It analyzes the changes which have led to an emphasis in policy on competitiveness, integrated approaches to economic decline and social exclusion, and the shift away from formula-driven funding mechanisms towards controversial competitive bidding. It also examines changes in governance practices, the spread of multisector partnerships, the new localism' and the emergence of a contract culture. The book concludes with a summary of contemporary policy themes and an assessment of the Labour Government's policy proposals.

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