negative co receptors and ligands

Negative Co-Receptors and Ligands

ISBN: , SKU: , AUTHOR: Ahmed, Rafi / Honjo, Tasuku, PUBLISHER: Springer, Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or downmodulation to avoid excessive damage to the host tissue. For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands have been identified that control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes biological functions as well as molecular mechanisms of these molecules.

Receptor Binding Techniques

ISBN: , SKU: , AUTHOR: Davenport, Anthony P., PUBLISHER: Humana Press, A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand binding assays and their analysis, quantitative autoradiography, and imaging receptors by positron emission tomography (PET). Highlights include phenotypic characterization of receptors in knockout mice, imaging receptors using green fluorescent protein and fluorescent resonance energy transfer, and quantitative analysis of receptor mRNA by TaqMan PCR. These book equips the researcher with techniques for exploring the unprecedented number of new receptor systems now emerging and the so-called "orphan" receptors whose activating ligand has not been identified.

Retinoids in Normal Development and Teratogenesis

ISBN: , SKU: , AUTHOR: Morriss-Kay, Gillian, PUBLISHER: Oxford University Press, USA, Retinoic acid is of major importance in the regulation of normal gene expression in both embryonic and adult cells, through binding to, and activation of, specific retinoic acid receptors in the nucleus. Other nuclear receptors may bind to different retinoids. In the embryo, tissue and stage-specific distribution patterns of the different receptors, and of the cytoplasmic retinoid binding proteins, provide an underlying basis for the richly varied and changing pattern of retinoid-related developmental gene expression. This book provides an up-to-date review of recent progress in understanding the roles of retinoids in both normal and abnormal differentiation, morphogenesis, and pattern formation. It integrates molecular, cellular and embryonic approaches.

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Mechanisms and Pathways of Heterotrimeric G Protein

ISBN: , SKU: , AUTHOR: Sprang, Stephen R., PUBLISHER: Academic Press, This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GƒNƒnƒnproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins.

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Immunology: A Short Course

ISBN: , SKU: , AUTHOR: Coico, Richard / Sunshine, Geoffrey, PUBLISHER: Wiley-Blackwell, "Immunology: A Short Course, Sixth Edition" introduces all the critical topics of modern immunology in clear and succinct yet comprehensive fashion. The authors offer a uniquely balanced coverage of classical and contemporary approaches, basic and clinical aspects. As with the previous editions, the strength of the text is in a complete review of modern immunology without burdening the reader with excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics illustrated by uniformly drawn, full-color illustrations, many brand new to this edition. The sixth edition of this successful textbook newly covers: Toll-like receptors, their ligands and intracellular activation pathways The key role of activation induced cytidine deaminase (AID) in somatic hypermutation and class switch recombination. The autoimmune regulator ("AIRE)" gene in self-tolerance and autoimmunity T and B cell activation and the immunological synapse, as well as characterization and mechanisms of action of T regulatory cells Praise for the previous edition: "This book is clearly a precious resource for undergraduate, graduate and medical students alike... For those who need an introduction to the fascinating world of immunology, this book should most certainly spark the interest." "ANNALS OF BIOMEDICAL ENGINEERING"..". an excellent beginner's guide... the authors have done a terrific job of providing an overview of the field." "YALE JOURNAL OF BIOLOGY AND MEDICINE"

Psychotherapy and the Religiously Committed Patient

ISBN: , SKU: , AUTHOR: Stern, E. Mark, PUBLISHER: Routledge, An enlightening book that discusses the positive and negative aspects of psychotherapeutic process with religiously commited patients. Indispensable reading for all therapists, teachers, and spiritually oriented professionals.

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Cell Electrophoresis

ISBN: , SKU: , AUTHOR: Bauer, Johann / Bauer, Johann, PUBLISHER: CRC Press, This book presents a summary of the application and instrumentation of cell electrophoresis. The method of making cell purification and characterization possible according to the cellular negative surface charge density is discussed, and ideas for future developments are explained. The negative electrostatic forces at cell surfaces provide information about cell-cell interaction, blood vessel sealing, cytokine actions, cell transformation, ion transport phenomena, and other biological phenomena. Recalculations of the physical principles of cell electrophoresis reveal possibilities for removing disruptive factors caused by electrical current, heat, and sedimentation. The introduction of computer technology, the performance of simultaneous two-parameter measurements, and the application of cell-friendly but current-inert buffer systems render the method more reliable and efficient.

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American Victorian Cottage Homes

ISBN: , SKU: , AUTHOR: Palliser Palliser & Co / Palliser &. Co, PUBLISHER: Dover Publications, Reprinted from a rare offering from a leading Northeastern architectural firm: front and side elevations, floor plans and descriptions of 50 "practical designs of low and medium priced houses," ranging from 2- to 11-room dwellings, most in the cottage style. With complete specifications for two, a sample contract, advertisements, and price estimates.

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Rodin

ISBN: , SKU: , AUTHOR: Grange Books, PUBLISHER: Grange Books, The French artist Auguste Rodin had a profound influence on 20th-century sculpture. His works are distinguished by their stunning strength and realism. Rodin refused to ignore the negative aspects of humanity, and his works confront distress and moral weakness as well as passion and beauty. A must-have book for art lovers and particularly fans of Rodin.

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Change Your Thinking: Overcome Stress, Combat Anxiety and

ISBN: , SKU: , AUTHOR: Edelman, Sarah, PUBLISHER: Marlowe & Company, Practicing psychologist Sarah Edelman clearly lays out how to use CBT to develop rational thought patterns in response to upsetting emotions and situations. By following the practical, easy-to-follow exercises and examples, you can take control of your thoughts, emotions, and feelings, and find more positive ways of dealing with life's hurdles-and a happier you.Change Your Thinking will teach you how to Fight negative and self-defeating beliefs to minimize your experience of upsetting emotions Recognize "thinking errors" that cause you unnecessary distress Learn how to dispute thinking errors with your behavior and rational thoughts Prevent negative thoughts and emotions from occurring Acknowledge and face the obstacles that prevent you from obtaining your goals Achieve a more balanced and happier life Whether you're faced with overwhelming feelings of worthlessness, frustration, anger, depression, or anxiety, CBT can help you change your thinking and make a difference in your life-beginning today.

Tissue Engineering, Stem Cells and Gene Therapies

ISBN: , SKU: , AUTHOR: Elcin, Y. Murat / Elc'in, Y. Murat / Elgin, Y. Murat, PUBLISHER: Springer, In recent years cell-based technologies have gained significant scientific attention, and have become a matter of intense public debate as well. Namely, (i) tissue engineering, the construction of tissues and whole organs using molecularly-designed resorbable biomaterials to create new tissue de novo with or without transplanting cells; (ii) the potential use of human embryonic stem cells for transplantation and regenerative medicine (with similar potential for adult-derived stem cells); (iii) and gene therapy, in relation with cell transplantation, have taken their places as the most discussed biomedical issues of the day. New findings in biomimetic materials, cell signalling pathways, extracellular matrix receptors and ligands, growth factors, and the human genome project are motivating the developments in these challenging research areas. This book includes manuscripts on tissue engineering, stem cells and gene therapies authored by world-renowned scientists of the field. The first section of the volume consists of four chapters giving perspectives for the current status and potential future of tissue engineering and stem cell technologies. The second section of the volume includes five chapters based on experimental and clinical data. In this section, the role of stem cells in liver tissue engineering, cell-based therapies in diabetes mellitus, and chronic degenerative diseases of the central nervous system, and adult-derived stem cell therapies are discussed. The two chapters of the third section focus on the biomarkers for tissue-engineered products, namely for tissue-engineered skin. The eight chapters of the fourth section discuss novel biomaterials developed for neural-, vascular-, aortic-, bone-, cartilage- and endocrine pancreas-tissue engineering applications. The last section of the book includes chapters on practical gene targeting applications, controlled release in gene therapy and tissue engineering, antibodies in cancer, acute-phase genes and phage-displayed peptide libraries. Proceedings of BIOMED a" The 9th International Symposium on Biomedical Science and Technology, held September , in Antalya, Turkey.

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