The Theoretical Foundation of Dendritic Function: The
ISBN: , SKU: , AUTHOR: Segev, Idan / Rinzel, John, PUBLISHER: Bradford Book, Wilfrid Rall was a pioneer in establishing the integrative functions ofneuronal dendrites that have provided a foundation for neurobiology in general andcomputational neuroscience in particular. This collection of fifteen previouslypublished papers, some of them not widely available, have been carefully chosen andannotated by Rall's colleagues and other leading neuroscientists. It brings togetherRall's work over more than forty years, including his first papers extending cabletheory to complex dendritic trees, his ground-breaking paper introducingcompartmental analysis to computational neuroscience, and his studies of synapticintegration in motoneurons, dendrodendritic interactions, plasticity of dendriticspines, and active dendritic properties.Today it is well known that the brain'ssynaptic information is processed mostly in the dendrites where many of the plasticchanges underlying learning and memory take place. It is particularly timely to lookagain at the work of a major creator of the field, to appreciate where thingsstarted and where they have led, and to correct any misinterpretations of Rall'swork. The editors' introduction highlights the major insights that were gained fromRall's studies as well as from those of his collaborators and followers. It asks thequestions that Rall proposed during his scientific career and briefly summarizes theanswers.The papers include commentaries by Milton Brightman, Robert E. Burke, William R. Holmes, Donald R. Humphrey, Julian J. B. Jack, John Miller, StephenRedman, John Rinzel, Idan Segev, Gordon M. Shepherd, and Charles Wilson.