Protein Conformation - No. 161
ISBN: , SKU: , AUTHOR: Ciba Foundation / Caba Foundation, PUBLISHER: John Wiley & Sons, Protein Conformation Chairman: F.M. Richards One of the major unsolved problems in biology and chemistry is how the amino acid sequence of a protein determines its three-dimensional structure, yet this structure is fundamental to the functioning and mechanism of action of enzymes, channels and receptors. Since the pioneering modelling work of Pauling in the s and the X-ray structure determinations by Kendrew and Perutz in the s, much structural information on proteins has been amassed. Several hundred protein structures have now been solved by X-ray crystallography and, more recently, NMR spectroscopy has had a significant impact on the study of structures of small proteins in solution. In this book, contributions from experts in the fields of X-ray crystallography, NMR spectroscopy, molecular modelling and protein engineering provide insight into current views on the protein folding problem and point to avenues for future progress. The use of molecular dynamics simulations to provide information about protein structure, dynamics and stability, and about protein-- protein interactions, is discussed. Other topics focused on include enzyme catalysis, site-directed mutagenesis as a tool in studies of protein conformation and stability, and recent developments in multidimensional NMR methodology. Related Ciba Foundation Symposia No 159 Catalytic antibodies Chairman: W.P. Jencks ISBN X No 158 Host-guest molecular interactions: from chemistry to biology Chairman: I.O. Sutherland ISBN No 145 Carbohydrate recognition in cellular function Chairman: E. Ruoslahti ISBN No 119 Synthetic peptides as antigens Chairman: G.L. Ada ISBN