improving the quality of cancer clinical trials workshop

Improving the Quality of Cancer Clinical Trials: Workshop

ISBN: , SKU: , AUTHOR: Patlak, Margie / Nass, Sharyl, PUBLISHER: National Academies Press, Scientists and clinicians seek a new paradigm that could improve the efficiency, cost-effectiveness, and overall success rate of cancer clinical trials, while maintaining the highest standards of quality. To explore innovative paradigms for cancer clinical trials and other ways to improve their quality, the National Cancer Policy Forum held a workshop, Improving the Quality of Cancer Clinical Trials, in Washington, DC. The main goals of the workshop were to examine new approaches to clinical trial design and execution that would: (1) better inform decisions and plans of those responsible for developing new cancer therapies (2) more rapidly move new diagnostic tests and treatments toward regulatory approval and use in the clinic (3) be less costly than current trials The resulting workshop summary will serve as input to the deliberations of an Institute of Medicine committee that will develop consensus-based recommendations for moving the field of cancer clinical trials forward.

Cardiac Safety of Noncardiac Drugs: Practical Guidelines for

ISBN: , SKU: , AUTHOR: Morganroth, Joel / Gussak, Ihor, PUBLISHER: Humana Press, Basic and clinical researchers from industry and academia detail the preclinical, clinical, and regulatory principles currently used to assess the cardiac safety of new drugs. The authors explain the parameters of cardiac safety at all stages of clinical research and drug development, including both the preclinical and pharmacogenomic aspects generally and the clinical methodologies and technical aspects for investigational drugs based on cardiac repolarization, as defined by the duration of the QTc interval. Additional chapters comprehensively review the application of electrocardiography in clinical research, the fundamentals of ECG interpretation in clinical trials, the statistical analysis plans for ECG data obtained in formal clinical trials, and the practical interpretation of the ECG results. Highlights include practical guidance on how to conduct a thorough ECG Trial in New Drug Development, how to use new ECG and web based technology in clinical research, and how to follow the new FDA requirements for ECG submissions.

Innovative Antimetabolites in Solid Tumours

ISBN: , SKU: , AUTHOR: Aapro, Matti S., PUBLISHER: Springer, The field of antimetabolites from basic science to clinical application is covered in this book. This continously evolving field represented the first kind of effective chemotherapy for human cancer. Aspects of biomodulation of 5-fluorouracil led to the recent development of agents such as gemcitabine, cladribine and fludarabine. The reader gains a good overview of a very important area for cancer treatment in one single volume. Acquista Ora

Cancer of the Stomach, a Clinical Study of 921 Operatively

ISBN: , SKU: , AUTHOR: Albert John Ochsner Frank Smithies, PUBLISHER: Kessinger Publishing LLC, NA

Hereditary Cancer Syndromes

ISBN: , SKU: , AUTHOR: Jatoi, Ismail / Martin, Ronald F., PUBLISHER: W.B. Saunders Company, This issue of the Surgical Clinics on Familial Cancer Syndromes will cover the following topics: cancer genetics; genetic testing for cancer susceptibility; genetic testing and privacy, employment, and insurance coverage; hereditary diffuse gastric cancer, hamartomatous polyposis syndromes, hereditary non-polyposis coli and familial adenomatous polyposis coli syndromes; management of hereditary breast cancer; multiple endocrine neoplasias; familial melanoma; the emerging role of prophylactic surgery in cancer prevention.

Understanding Cancer Therapies

ISBN: , SKU: , AUTHOR: Chan, Helen S. L., PUBLISHER: University Press of Mississippi, Cancer is one of the world's most dreaded diseases. Yet the past two decades have seen major revolutions in cancer therapy and steadily growing hopes for a cure. This book, written in easily understood language, provides an extensive look at the way medical professionals are treating the disease today. Chapters provide: Rationale and principles integral to disease management Biological basis for different therapies Explanations of the protocols behind radiation, chemotherapy, drug treatments, and surgery Logic behind therapies chosen for such different kinds of cancer as leukemia, lymphoma, retinoblastoma, hepatoblastoma, germ-cell tumors, soft-tissue and bone sarcomas, among others Information on the most current procedures Further reading and resources for patients and families Chapters on clinical practice discuss the differing approaches to cancer in adults and in children. The book closes with a survey of some of the most experimental therapies and the status of the search for a cure. Helen S. L. Chan, M.D., of Toronto, Canada, is a staff hematologist/oncologist and professor at the University of Toronto's Hospital for Sick Children. Her work has been published in "New England Journal of Medicine," "Journal of Clinical Oncology," "Cancer Research," and other periodicals.

Cancer: Principles & Practice of Oncology, Volume 1: Annual

ISBN: , SKU: , AUTHOR: DeVita, Vincent T., Jr. / Lawrence, Theodore S. / Rosenberg, Steven A., PUBLISHER: Lippincott Williams & Wilkins, Introducing the first volume of a new series, Cancer: Principles & Practice of Oncology--Advances in Oncology. This series of annual volumes will focus on the most significant changes in oncologic research and practice that have taken place during the preceding year. Each volume identifies scientific and clinical areas in oncology that are rapidly changing and show a high potential for affecting the management of cancer patients in the future. These areas may reflect current controversies in oncology and every effort is made to provide clear direction for the practicing oncologist. Acquista Ora

Cross-Over Trials in Clinical Research

ISBN: , SKU: , AUTHOR: Senn, S. J. / Senn, Stephen, PUBLISHER: John Wiley & Sons, Statistics in Practice A new series of practical books outlining the use of statistical techniques in a wide range of application areas: Human and Biological SciencesEarth and Environmental SciencesIndustry, Commerce and FinanceCross-over Trials in Clinical Research Stephen Senn Biometrics, Medical Department, CIBA-Geigy Ltd, Basle, Switzerland Cross-over Trials in Clinical Research provides a practical introduction to this important tool within the pharmaceutical industry. Aimed at guiding practitioners in the methods of using cross-over designs efficiently, this book presents a fresh insight into how such trials may be designed and analysed. Key features of this comprehensive treatment are: A focus on the two-period AB/BA design, including the most up-to-date developments in this topic.Important aspects of special design-- graphical and tabular presentation of trials, robust approaches to analysis, and practical issues in planning.Direct relevance to drug development with an approach rooted firmly in biology and pharmacokinetics rather than stressing the mathematical aspects.All techniques included are discussed and illustrated in detail with many practical examples drawn from the author' s wide-ranging experience.This book will prove an invaluable reference to all statisticians and researchers in the pharmaceutical industry. It will also appeal to physicians involved in clinical research. Acquista Ora

Improving Care in the Nursing Home: Comprehensive Reviews of

ISBN: , SKU: , AUTHOR: Rubenstein, Laurence Z. / Wieland, Darryl, PUBLISHER: Sage Publications (CA), This volume provides systematic reviews of the state of clinical and health services research, in particular patient-care problem areas pertinent to nursing homes. Each chapter defines progress on a specific nursing home clinical problem and provides a critical synthesis and review of research information. Topics covered include: medication use; infection control; pressure ulcers; falls; urinary incontinence; and behavioural problems.

Thoracic Malignancies: Radiation Medicine Rounds: Volume 1,

ISBN: , SKU: , AUTHOR: Schild, Steven E., PUBLISHER: Demos Medical Publishing, Thoracic Malignancies is a review title providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of thoracic malignancy oncology. The goal is to provide authoritative, thorough assessment of a wide range of "hot topics" and emerging new data. The book addresses the multi-disciplinary nature of the care of these tumors. There is representation from radiation oncology, medical oncology, and surgery ensuring a well-rounded summarization of current practice. Included are chapters on lung cancer, esophageal cancer, and Thymomas covering the vast majority of thoracic tumors. The multi-disciplinary nature of the articles provides readers with an up to date summary and a well-rounded review regarding these tumors and their care. Expert authors provide reviews and assessments of the most recent data and its implications for current clinical practice, along with insights into emerging new trends of importance for the near future.

Pathogenesis and Clinical Practice in Gastroenterology

ISBN: , SKU: , AUTHOR: Ferkolj, I. / Galle, P. R. / Gangl, A., PUBLISHER: Springer, The translation of new molecular understanding of disease into clinical practice in gastroenterology is a special challenge. The Falk Symposium No. 160, entitled a Pathogenesis and Clinical Practice in Gastroenterologya (TM), held June in PortoroA3/4, Slovenia, provided a stimulating framework to bridge discussions from bench to bedside. The proceedings of the symposium are contained in this book, and the unifying theme is the growing understanding of inflammation as a driving force in chronic disease leading to disability and malignancy. Aspects of early detection - endoscopically or via molecular markers - are covered as well as in-depth discussions of the validation of new findings in clinical practice. Whilst on a molecular basis gastroenterologists and hepatologists try to shed light on the same intracellular pathways, clinical implications such as surveillance of cancer in IBD or chronic hepatitis with cirrhosis have to be tailored to specific needs. New therapeutic agents - approved or on the horizon of early clinical studies - will dramatically change the options of patients with chronic disease such as Crohna (TM)s disease, viral hepatitis or hepatocellular carcinoma.

Violence Prevention in Low- And Middle-Income Countries:

ISBN: , SKU: , AUTHOR: Planning Committee for a Workshop on Vio / Institute Of Medicine, PUBLISHER: National Academies Press, The current state of science in violence prevention reveals progress, promise, and a number of remaining challenges. In order to fully examine the issue of global violence prevention, the Institute of Medicine in collaboration with Global Violence Prevention Advocacy, convened a workshop and released the workshop summary entitled, "Violence Prevention in Low-and Middle-Income Countries." The workshop brought together participants with a wide array of expertise in fields related to health, criminal justice, public policy, and economic development, to study and articulate specific opportunities for the U.S. government and other leaders with resources to more effectively support programming for prevention of the many types of violence. Participants highlighted the need for the timely development of an integrated, science-based approach and agenda to support research, clinical practice, program development, policy analysis, and advocacy for violence prevention.

Henry Kaplan and the Story of Hodgkin's Disease

ISBN: , SKU: , AUTHOR: Jacobs, Charlotte DeCroes, PUBLISHER: Stanford University Press, In the s, ninety-five percent of patients with Hodgkin's disease, a cancer of lymph tissue which afflicts young adults, died. Today most are cured, due mainly to the efforts of Dr. Henry Kaplan. "Henry Kaplan and the Story of Hodgkin's Disease" explores the life of this multifaceted, internationally known radiation oncologist, called a "saint" by some, a "malignant son of a bitch" by others. Kaplan's passion to cure cancer dominated his life and helped him weather the controversy that marked each of his innovations, but it extracted a high price, leaving casualties along the way. Most never knew of his family struggles, his ill-fated love affair with Stanford University, or the humanitarian efforts that imperiled him. Today, Kaplan ranks as one of the foremost physician-scientists in the history of cancer medicine. In this book Charlotte Jacobs gives us the first account of a remarkable man who changed the face of cancer therapy and the history of a once fatal, now curable, cancer. She presents a dual drama --the biography of this renowned man who called cancer his "Moby Dick" and the history of Hodgkin's disease, the malignancy he set out to annihilate. The book recounts the history of Hodgkin's disease, first described in : the key figures, the serendipitous discoveries of radiation and chemotherapy, the improving cure rates, the unanticipated toxicities. The lives of individual patients, bold enough to undergo experimental therapies, lend poignancy to the successes and failures. Acquista Ora

Finding Your Way Through Cancer: An Expert Cancer

ISBN: , SKU: , AUTHOR: Kneier, Andrew, PUBLISHER: Celestial Arts, Andrew Kneier, pioneering psychologist at the University of California, San Francisco, has been therapist to thousands with cancer. This groundbreaking book delves into the particular concerns that patients with the disease (and their families) face, time and again, and explores suffering and resilience. As the only clinical psychologist at the UCSF Comprehensive Cancer Center for many years, Dr. Andrew Kneier met with nearly patients in one-on-one sessions--almost certainly more than any other therapist in the country. This book is the distillation of their collective insights, anxieties, and more, based on the top ten topics that cancer patients bring up in therapy. It addresses questions such as: How can God exist in a world with such suffering? What should I tell my family? Can any good come from this? How do I continue my life story? This book will serve as a "therapist between two covers" for cancer patients, survivors, their families, doctors, and anyone else who needs the wisdom of the most experienced cancer therapist.

Recent Trends in Algebraic Development Techniques: 15th

ISBN: , SKU: , AUTHOR: Cerioli, M. / Reggio, G. / Cerioli, Maura, PUBLISHER: Springer, This book constitutes the thoroughly refereed post-workshop proceedings of the 15th International Workshop on Algebraic Development Techniques, WADT , held jointly with the General Workshop of the ESPRIT Working Group CoFI in Genova, Italy, in April . The book presents 16 papers selected from 32 workshop presentations. Among the topics addressed are formal specification, specification languages, term rewriting, and proof systems.

Transfusion Medicine: Case Studies and Clinical Management

ISBN: , SKU: , AUTHOR: Mijovic, Aleksandar, PUBLISHER: Springer, The purpose of this clinical transfusion medicine handbook is to take the reader through a variety of clinical problems, each one likely to be encountered in a busy teaching hospital. The reader follows the stream of clinical and laboratory data, developing the ability for critical thinking which leads him/her to diagnosis and appropriate management.The book is a lively illustration of various clinical problems in transfusion medicine, including immune complications, microbiological problems, blood component use, apheresis techniques, and management of complex situations such as multiple trauma, sickle cell crisis, and organ transplantation.Each case is carefully chosen and presented, with incorporated questions, leading the reader towards solution of the problem in a logical and didactic manner

Textbook of Biochemistry: With Clinical Correlations

ISBN: , SKU: , AUTHOR: Devlin, Thomas M., PUBLISHER: Wiley-Liss, This book offers a comprehensive and current view of mammalian biochemistry. It includes unique "Clinical Correlations" -- examples of clinical manifestations of biochemical defects -- along with extensive illustrations to provide a complete picture of all aspects of biochemistry. Contains new clinical correlations and review questions. -- New, full color illustrations program. -- A "Devlin" Web site provides online discussions, new material not found in the book, and other information relevant to the book.

Water Conservation, Reuse, and Recycling: Proceedings of an

ISBN: , SKU: , AUTHOR: Committee on U S-Iranian Workshop on Water Conservation Reus / Office for Central Europe and Eurasia Development Security a / Nati, PUBLISHER: National Academies Press, In December , a group of specialists on water resources from the United States and Iran met in Tunis, Tunisia, for an interacademy workshop on water resources management, conservation, and recycling. This was the fourth interacademy workshop on a variety of topics held in , the first year of such workshops. Tunis was selected as the location for the workshop because the Tunisian experience in addressing water conservation issues was of interest to the participants from both the United States and Iran. This report includes the agenda for the workshop, all of the papers that were presented, and the list of site visits.

Clinical Methods and Practicum in Speech-Language Pathology

ISBN: , SKU: , AUTHOR: Hegde, M. N. / Davis, Deborah, PUBLISHER: Cengage Learning, For student clinicians and clinical supervisors alike, clinical practicum in speech-language pathology is a learning experience that involves clearly defined expectations, ethical principles, and effective methods of treatment. This comprehensive resource provides a well-rounded discussion of the clinical practicum, including basic organization and competency guidelines, ethical and behavioral conduct between the student and supervisor and with clients, and multicultural issues encountered in clinical practice. Also presented are effective clinical methods in the treatment, control, and maintenance of communicative disorders. Acquista Ora

Agronomy of Grassland Systems

ISBN: , SKU: , AUTHOR: Pearson, C. J., PUBLISHER: Cambridge University Press, Agronomy of Grassland Systems presents a broad overview of grasslands agronomy incorporating both grassland and animal productivity within the context of farming systems. The authors, both experienced in the field of agriculture, examine the generation, vegetative growth, flowering, and seed production of grasslands, as well as mineral nutrition, pasture quality, and animal intake. The management implications of forage-animal interactions are considered with respect to improving the efficiency of livestock production, together with a concluding chapter on grasslands management within the framework of farming systems.

Microbial Technology in the Developing World: An

ISBN: , SKU: , AUTHOR: Dasilva / Dasilva, E. J. / Dommergues, Y. R., PUBLISHER: Oxford University Press, USA, The development of recombinant DNA technology has created a new upsurge of interest in biotechnology--the harnessing of micro-organisms and plant microbial cells for the production of specific materials of direct use to man or for the improvement of the environment. Discussing both traditional and emerging aspects of the science, this unique book reviews numerous exciting applications of biotechnology in developing countries, emphasizing that a small improvement in energy efficiency, utilization, or generation may have far-reaching effects in improving the quality of life of people in poor communities.

Breast Cancer [With Access Code]

ISBN: , SKU: , AUTHOR: Jacobs, Lisa / Finlay, Christina A. / Yang, Stephen C., PUBLISHER: W.B. Saunders Company, Each volume in the Early Detection and Treatment of Cancer Series is packed with practical, authoritative information designed to cover the full range of diagnostic procedures, including pathologic, radiologic, bronchoscopic, and surgical aspects. You'll be able to determine the safest, shortest, least invasive way to reach an accurate diagnosis; stage the disease; and choose the best initial treatment for early stages. Based on current evidence in the literature, authors provide clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed to diagnose and stage each type of cancer. Practical, authoritative, and highly-illustrated, this volume in the brand new Early Detection and Treatment of Cancer series covers current protocols and the latest advances in diagnostic imaging and molecular and serologic markers for breast cancer. Apply expert advice on the best "next-step" plan for different presentations and tips for less invasive protocols. Get clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed for accurate diagnosis and staging. Clear figures, tables, and boxes illustrate step-by-step care of the full range of problems encountered. Better manage your patients with procedural video clips and more on the included CD-ROM. The small size and convenient format make this an ideal purchase for diagnostic reference.

Clinical Thrombosis

ISBN: , SKU: , AUTHOR: Kwaan, Hau C. / Samama, Meyer / O'Kelly, Charles J., PUBLISHER: CRC Press, State-of-the-art information on the topic of clinical thrombosis, including an introductory portion dealing with the principles of hemostasis and the pathogenesis of thrombosis, is presented in this text. The use of thrombolytic therapy in acute myocardial infarction is discussed. Other significant advances, such as the identification and understanding of the risk factors contributing to thrombosis such as Protein C and S deficiency, lupus anticoagulants, immune heparin-induced thrombocytopenia, new diagnostic techniques and newer modalities of therapy, are described. Clinical and pathophysiologic features of thrombosis disorders and special situations involving multiple organs are covered. This book also clarifies and updates the usefulness of the various diagnostic techniques.

Prostate Biopsy Interpretation: Dosage Calculation,

ISBN: , SKU: , AUTHOR: Epstein, Jonathan I. / Yang, Ximing J. / Yant, Ximing J., PUBLISHER: Lippincott Williams & Wilkins, The thoroughly revised, updated Third Edition of this acclaimed reference retains the goal of the original--a practical, state-of-the-art, superbly illustrated guide to prostate biopsy interpretation. Drs. Epstein and Yang, two leading experts, provide comprehensive, current information on the classification, clinical features, prognosis, and evaluation of difficult and unusual as well as common lesions. Coverage includes normal, inflammatory, tumor-like, benign, and malignant conditions. This edition contains more tables to aid in differential diagnosis of similar lesions. The authors have also added new information on the Gleason grading system...predictive factors on needle biopsy...ancillary studies that can be performed on a needle biopsy...significance of ductal adenocarcinoma on needle biopsy...treatment effect on prostate cancer and its prognostic significance...use of newly described antibodies...the new classification system for stromal tumors of the prostate...and clinical parameters as they relate to needle biopsy findings. A bound-in CD-ROM contains more than full-color images--all with detailed legends and 100 with checklists of points in favor of and against a cancer diagnosis.

Dragon Age Dice Set D6 (6)

In the box you will find six beautiful dice, emblazoned with iconography from the world of Thedas, setting for BioWare',s Dragon Age fantasy video game! Four of these high-quality, durable dice carry the symbols of the Circle of Magi and the Templars. The remaining two bear the Grey Warden Griffon and the iconic Blood Dragon. Manufactured by Q-workshop, and perfect for any fan of Dragon Age, these also serve as two sets of dice for Green Ronin',s Dragon Age RPG!

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