computer techniques in preclinical and clinical drug

Computer Techniques in Preclinical and Clinical Drug

ISBN: , SKU: , AUTHOR: Jackson, Robert C. / Jackson, PUBLISHER: Informa Healthcare, It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, How can we use computational methods to improve the success rate in drug development? Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.

Cardiac Safety of Noncardiac Drugs: Practical Guidelines for

ISBN: , SKU: , AUTHOR: Morganroth, Joel / Gussak, Ihor, PUBLISHER: Humana Press, Basic and clinical researchers from industry and academia detail the preclinical, clinical, and regulatory principles currently used to assess the cardiac safety of new drugs. The authors explain the parameters of cardiac safety at all stages of clinical research and drug development, including both the preclinical and pharmacogenomic aspects generally and the clinical methodologies and technical aspects for investigational drugs based on cardiac repolarization, as defined by the duration of the QTc interval. Additional chapters comprehensively review the application of electrocardiography in clinical research, the fundamentals of ECG interpretation in clinical trials, the statistical analysis plans for ECG data obtained in formal clinical trials, and the practical interpretation of the ECG results. Highlights include practical guidance on how to conduct a thorough ECG Trial in New Drug Development, how to use new ECG and web based technology in clinical research, and how to follow the new FDA requirements for ECG submissions.

Nurse's Clinical Guide: Dosage Calculations

ISBN: , SKU: , AUTHOR: Erickson, Belle / Todd, Catherine M. / Erickson, PUBLISHER: Lippincott Williams & Wilkins, This guide covers drug labels and the latest drug delivery methods, such as fentanyl patches and needleless injections. Also included is a review of dimensional analysis. In addition, nurses find a refresher of math and basic dosage principles, considerations for special-needs patients, and practice exercises. Contents include a review of mathematics; systems of drug measurements; the administration process; calculating enteral drug dosages; calculating parenteral drug dosages; solutions, ointments, and patches; other considerations; appendices; references; index.

Pharmacotherapeutics: Clinical Decision-Making in Nursing

ISBN: , SKU: , AUTHOR: Gutierrez, Kathleen / Connor, Maura, PUBLISHER: W.B. Saunders Company, This new text integrates knowledge of pathophysiology and pharmacology with specific drug and patient variables to help nurses understand the rationale for choosing one drug over another. As a result of this knowledge, nurses are able to use clinical judgment to provide better patient care.Using a body system organization, it explains each of the major drug groups, the conditions for which they are used, and their effects on the various body systems. For each given disease or condition, the text walks the reader through treatment objectives, pharmacotherapeutic options, side effects, and the critical thinking process, analysis, implementation, and evaluation.

Clinical Thrombosis

ISBN: , SKU: , AUTHOR: Kwaan, Hau C. / Samama, Meyer / O'Kelly, Charles J., PUBLISHER: CRC Press, State-of-the-art information on the topic of clinical thrombosis, including an introductory portion dealing with the principles of hemostasis and the pathogenesis of thrombosis, is presented in this text. The use of thrombolytic therapy in acute myocardial infarction is discussed. Other significant advances, such as the identification and understanding of the risk factors contributing to thrombosis such as Protein C and S deficiency, lupus anticoagulants, immune heparin-induced thrombocytopenia, new diagnostic techniques and newer modalities of therapy, are described. Clinical and pathophysiologic features of thrombosis disorders and special situations involving multiple organs are covered. This book also clarifies and updates the usefulness of the various diagnostic techniques.

Essentials of Clinical Pharmacology in Nursing [With Disk

ISBN: , SKU: , AUTHOR: Williams, Bradley R. / Baer, Charold L. / Williams, Robert, PUBLISHER: Lippincott Williams & Wilkins, Concise presentation of basic pharmacologic information for the student. Units 1 and 2 address fundamentals of pharmacology and drag administration. Units 3- 16 group drags by therapeutic classification with each chapter covering pharmacokinetics, pharmacodynamics, pharmacotherapeutics, adverse drug reactions and nursing process steps in administering drugs. Additional chapters cover dosage measurements and calculations, administration routes and techniques, uncategorized drugs and more. Disk has questions and exercises for self-study.

Transfusion Medicine: Case Studies and Clinical Management

ISBN: , SKU: , AUTHOR: Mijovic, Aleksandar, PUBLISHER: Springer, The purpose of this clinical transfusion medicine handbook is to take the reader through a variety of clinical problems, each one likely to be encountered in a busy teaching hospital. The reader follows the stream of clinical and laboratory data, developing the ability for critical thinking which leads him/her to diagnosis and appropriate management.The book is a lively illustration of various clinical problems in transfusion medicine, including immune complications, microbiological problems, blood component use, apheresis techniques, and management of complex situations such as multiple trauma, sickle cell crisis, and organ transplantation.Each case is carefully chosen and presented, with incorporated questions, leading the reader towards solution of the problem in a logical and didactic manner

Handbook of Critical Care Nursing

ISBN: , SKU: , AUTHOR: Moreau, David / Springhouse, PUBLISHER: Lippincott Williams & Wilkins, For each alphabetically organized condition, nurses learn pathophysiology, clinical assessment, the diagnostic tests likely to be ordered, treatment and care (including medical and nursing interventions), prognosis, and discharge planning. Pathophysiology drug charts alert readers to significant drugs and protocols used to treat major body system disorders. Readers will find discussions of ethical problems, current trends, a helpful index, and more. Appendices offer crucial data on common emergency drugs and laboratory values, therapeutic and toxic drug levels, normal hemodynamic variables, and commonly encountered nursing diagnoses.

Cross-Over Trials in Clinical Research

ISBN: , SKU: , AUTHOR: Senn, S. J. / Senn, Stephen, PUBLISHER: John Wiley & Sons, Statistics in Practice A new series of practical books outlining the use of statistical techniques in a wide range of application areas: Human and Biological SciencesEarth and Environmental SciencesIndustry, Commerce and FinanceCross-over Trials in Clinical Research Stephen Senn Biometrics, Medical Department, CIBA-Geigy Ltd, Basle, Switzerland Cross-over Trials in Clinical Research provides a practical introduction to this important tool within the pharmaceutical industry. Aimed at guiding practitioners in the methods of using cross-over designs efficiently, this book presents a fresh insight into how such trials may be designed and analysed. Key features of this comprehensive treatment are: A focus on the two-period AB/BA design, including the most up-to-date developments in this topic.Important aspects of special design-- graphical and tabular presentation of trials, robust approaches to analysis, and practical issues in planning.Direct relevance to drug development with an approach rooted firmly in biology and pharmacokinetics rather than stressing the mathematical aspects.All techniques included are discussed and illustrated in detail with many practical examples drawn from the author' s wide-ranging experience.This book will prove an invaluable reference to all statisticians and researchers in the pharmaceutical industry. It will also appeal to physicians involved in clinical research. Acquista Ora

Clinical Methods and Practicum in Speech-Language Pathology

ISBN: , SKU: , AUTHOR: Hegde, M. N. / Davis, Deborah, PUBLISHER: Cengage Learning, For student clinicians and clinical supervisors alike, clinical practicum in speech-language pathology is a learning experience that involves clearly defined expectations, ethical principles, and effective methods of treatment. This comprehensive resource provides a well-rounded discussion of the clinical practicum, including basic organization and competency guidelines, ethical and behavioral conduct between the student and supervisor and with clients, and multicultural issues encountered in clinical practice. Also presented are effective clinical methods in the treatment, control, and maintenance of communicative disorders. Acquista Ora

Physician Assistant's Drug Handbook

ISBN: , SKU: , AUTHOR: Springhouse Publishing, PUBLISHER: Springhouse Corporation, This complete guide gives full prescribing data for more than generic and brand name drugs. Includes unlabeled drug uses, highlighted dosage adjustment information, italicized interacting agents, adverse reactions categorized five ways for safety, and a four-way index for quick look-up -- by generic name, trade name, drug class, or disease. Alphabetically organized drug monographs cover generic and trade names; pharmocologic and therapeutic classifications; controlled substance schedule (where appropriate); pregnancy risk category; dosage form; indications, route, and dosage; pharmacodynamics; pharmacokinetics; contraindications and precautions; interactions; effects on diagnostic tests; adverse reactions; overdose and treatment; and special considerations, including patient education and specific instructions for pediatric, geriatric, and breast-feeding patients. Contents include clinical reviewers and consultants, foreword, how to use this book, pharmacology overview, pediatric and geriatric drug therapy, effective prescribing practices, generic drug entries in alphabetical order, a full-color photoguide to more than 320 pills, pharmacologic classes, prescribing authority by state, selected analgesic combination products, topical drugs, immunization schedule, therapeutic drug monitoring guidelines, therapeutic management guidelines, creatinine clearance calculations, pharmaceutical companies listing (drug information contact numbers and Web sites).

Empirically Based Assessment of Child and Adolescent

ISBN: , SKU: , AUTHOR: Achenbach, Thomas M. / McConaughy, Stephanie H., PUBLISHER: Sage Publications (CA), The authors present an empirically based assessment approach that provides concrete guidelines for clinical work. Using ratings, direct observations and interviews, they discuss methods for assessing childhood dysfunction based on a comprehensive integration of information from parents, teachers and children. The material is presented with clinical illustrations that convey the use of specific assessment techniques for intake, case evaluation, decisions about treatment, management and follow-up.

Drug Facts and Comparisons: Pocket Version

ISBN: , SKU: , AUTHOR: Facts & Comparisons, PUBLISHER: Lippincott Williams & Wilkins, Drug Facts and Comparisons: Pocket Version is the ideal resource for the drug information you need at the point of care. Abridged from Drug Facts and Comparisons, this handy pocket version allows you to confirm critical drug information immediately, in a quick-reference format. Pocket DFC features the most commonly used drugs, conveniently addressing topics that demand attention. Features include: Rx and OTC drugs; similar products listed together in tables for easy comparison; more than brand name and 600 generic drugs; dozens of convenient charts; and more than 300 monographs.

Instant Psychopharmacology: Up-To-Date Information about the

ISBN: , SKU: , AUTHOR: Diamond, Ronald J., PUBLISHER: W. W. Norton & Company, A revision of our best-selling brief guide to all the new medications, this straightforward, easy-to-understand book teaches nonmedical therapists, clients, and clients' families how different psychotropic drugs work. This handy guide provides information on side effects, indications for use, drug-drug interactions, and suggested dosages. All medical information has been updated for the new volume. Also included are tips on taking medication, practical advice on the client/clinical/psychiatrist relationship, and numerous updated tables and graphs on medications' profiles, generic and brand names, prices, and side effects. Acquista Ora

Drug Interaction Facts& #;: Published by Facts and

ISBN: , SKU: , AUTHOR: Tatro, David S. / Published by Facts and Comparisons, PUBLISHER: Lippincott Williams & Wilkins, This comprehensive reference includes clinically significant drug interactions as well as interactions that are suspected but unsubstantiated. Every monograph includes a concise synopsis of the onset, severity and documentation of the drug interaction. The comprehensive index permits rapid screening for potential interactions by class, generic drug or trade name. All information has been thoroughly reviewed and evaluated by an interdisciplinary panel of experts.

Principles and techniques of Biochemistry and

Principles and techniques of Biochemistry and molecular biology in ottimo stato, mai usato quindi no sottolineature e pieghe a 20 euro. Marcello 346/ Dopo le ore 16 Grazie. NO MAIL.

Workbook for Heller/Veach's Clinical Medical Assisting: A

ISBN: , SKU: , AUTHOR: Heller, Michelle / Veach, Lynette M. / Heller, Johnny, PUBLISHER: Cengage Learning, Specifically designed to reinforce and apply concepts, this workbook will give you the opportunities and confidence to think on a higher level and develop problem solving skills, while learning the clinical competencies and technical skills needed to succeed on the job. Competency checklists for each procedure track the clinical and general competencies designated by ABHES and CAAHEP.

animazione al computer

A. Watt - M. Watt advanced animation and rendering techniques theory and practice in lingua inglese

Principles and techniques of Biochemistry and molecular...

Principles and techniques of Biochemistry and molecular biology in ottimo stato, mai usato quindi no sottolineature e pieghe a 20 euro. Marcello 346/ NO MAIL.

Mosby's Handbook of Drug-Herb and Drug-Supplement

ISBN: , SKU: , AUTHOR: Health Gate Data Corporation / Harness, Richard / Bratman, Stven, PUBLISHER: Mosby, With an increasing number of patients combining herbal treatments with prescribed medications, reliable information on herb/supplement and pharmaceutical interactions is much needed. This portable reference is organized alphabetically by drug name and features an entry for each drug-herb/drug-supplement combination that has a proven interaction. Each entry is rated on a scale of 1 to 4 to show the severity of the interaction and includes information on related drugs, an interaction summary, a discussion of the interaction, management suggestions, and references. In addition to the core material, there are also several helpful appendices on interactions by herb or supplement, nutrient depletions, and drug-herb add-on depressant interactions.

Principles of Laparoscopic Surgery: Basic & Advanced

ISBN: , SKU: , AUTHOR: Arregui, Maurice E. / Fitzgibbons, Robert J. Jr., PUBLISHER: Springer, This book brings together the most up-to-date information available on basic and advanced laparoscopic techniques. Enhanced by over 750 illustrations and written by international, interdisciplinary experts, this is the definitive reference on: basic laparoscopy techniques; laparoscopy and thoracoscopy in general surgery; laparoscopy in surgical subspecialties (gynecology, urology, angioscopy); plus a special section on technological aspects of laparoscopy. Throughout this authoritative volume, the reader will find in-depth reviews of the literature and extensive clinical and scientific data on the rationale for using laparoscopic surgical procedures.

Insider's Guide to Graduate Programs in Clinical and

ISBN: , SKU: , AUTHOR: Mayne, Tracy J. / Norcross, John C. / Sayette, Michael A., PUBLISHER: Guilford Publications, This perennial bestseller is the resource students count on for the most current information on applying to doctoral programs in clinical or counseling psychology in the US and Canada. The new edition features over 15 new programs; additional data on acceptance rates and enrollment rates; the latest information on financial assistance and loans; 42 new website listings; and updated appendices on research areas and clinical opportunities.

Clinical Laboratory Tests: Values and Implications

ISBN: , SKU: , AUTHOR: Springhouse Publishing, PUBLISHER: Springhouse Corporation, More than 350 alphabetically organized laboratory tests. Each entry gives the test's common name (and secondary names when appropriate); description; purpose and indications; patient preparation; procedures and equipment used; guidelines for sample and specimen collection; normal values; implications of results; post-test care; and factors that can affect test results. The 18 added tests include polymerase chain reaction and cancer antigen-125. Charts alert readers to drug blood levels, test results, diagnostic criteria, and more. Appendices feature critical laboratory test values and a guide to abbreviations.

Flow Cytometry: Advanced Research and Clinical Applications,

ISBN: , SKU: , AUTHOR: Yen / Yen, Yen / Yen, Andrew, PUBLISHER: CRC Press, The current technology and its applications in flow cytometry are presented in this comprehensive reference work. Described in explicit detail are the instrumentation and its components, and applications of the technology in cell biology, immunology, pharmacology, genetics, hematology and clinical medicine. Methods for data analysis, including both hardware and software, and explicit experimental techniques for making specific measurements are presented. Material is divided by topic into two volumes: Volume I covers instrumentation, genetics, and cell structure; Volume II contains material on cell function studies by flow cytometry. This reference is essential for both the novice and the experienced investigator using flow cytometry in research, and for students of cell biology, biomedical engineering, and medical technology.

Laboratory Manual and Workbook in Microbiology: Applications

ISBN: , SKU: , AUTHOR: Granato, Paul A. / Morton, Verna / Mizer, Helen Eckel, PUBLISHER: McGraw-Hill Science/Engineering/Math, The emphasis of this lab manual is on the basic principles of diagnostic microbiology for students preparing to enter an allied health field. Students are led through a series of exercises that allow them to learn basic microbiology techniques and to practice safety in the laboratory and hospital environment. It remains oriented primarily toward meeting the interests and needs of those who will be directly involved in patient care and who wish to learn how microbiological principles should be applied in the practice of their professions. The authors have emphasized the purposes and function of the clinical microbiology laboratory in the diagnosis of infectious diseases. The exercises illustrate as simply as possible the nature of laboratory procedures used for isolation and identification of infectious agents as well as the principles of asepsis, disinfection and sterilization. Attention is given to the role of the health professional in regard to appropriate collection of clinical specimens and the applications of aseptic and disinfectant techniques as they relate to patient care.

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